Syracuse is the name of two major cities in the world.

• The original Syracuse, Italy on the Italian island of Sicily
• The city Syracuse, New York in the United States

There are also six small municipalities in the United States by this name:

• Syracuse, Indiana
• Syracuse, Kansas
• Syracuse, Missouri
• Syracuse, Nebraska
• Syracuse, Ohio
• Syracuse, Utah

Syracuse also can be used to refer to Syracuse University, in Syracuse, New York. The university has a registered trademark on the word "Syracuse," if used to mean Syracuse University.