Seneca has several significant meanings:

• Seneca the Elder
• Seneca the Younger
• Seneca tribe
• Seneca crater
• Seneca (plant)
• Seneca College, Toronto, Ontario

Places in the United States of America:

• Seneca, Pennsylvania
• Seneca, South Carolina
• Seneca, Wisconsin
• Seneca County, New York
• Seneca, New York
• Seneca Lake
• Seneca Falls (village), New York
• Senecaville, Ohio