SPA can refer to:

• School of Planning and architecture is India's premier Architecture and city-planning institutions. Located in Delhi
• Software Publishers Association, now known as the Software and Information Industry Association (SIIA).
• Special Protection Area - an important Nature reserve
• the Circuit de Spa-Francorchamps, an auto racing venue in Belgium; or
• the SPA 24 Hours race held there
• Saint Paul Academy and Summit School, a private K-12 school in Saint Paul, Minnesota
• saddle point approximation in quantum field theory
• Latin for 'sanus per aquam' meaning 'in good health through water', often found as an addition to a gym's name indicating that they have a wellness/recreation area including a sauna, swim hall etc.