SC, Sc, or sc may stand for:

• Sardinian language (ISO 639 alpha-2, sc)
• Scandium (Sc symbol for the chemical element)
• The Security Council of the United Nations
• Senior Counsel
• Serial compatibility
• Seychelles (ISO 3166-1 alpha-2 country code, SC)
• Shortcut
• South Carolina (U.S. state)
• Special Constable
• Splinter Cell, a computer game by Ubisoft
• SportsCenter
• Springfield College
• StarCraft (computer game)
• Student Center, the
• Sumter and Choctaw Railway
• The Supreme Court, in some countries
• University of Southern California
• A type of a fiber optic cable jack (SC) of a push-pull coupling style