A reflux suppressant is any one of a number of drugs used to combat oesophageal reflux . Commonly, following ingestion a 'raft' of alginic acid is created, floating on the stomach contents by carbon dioxide released by the drug. This forms a mechanical barrier to further reflux. Some preparations also contain antacids to protect the oesophagus.

Reflux can also be co-incidentally reduced by the prokinetic agent and antidopaminergics .