Ophelia means several things:

• Ophelia is a fictional character in William Shakespeare's play Hamlet.
• Ophelia (painting) is a painting by John Everett Millais
• Ophelia is a moon of Uranus.
• 171 Ophelia is an asteroid.
• Ophelia is an album by Natalie Merchant
• Reviving Ophelia is a 1995 book by Mary Pipher which discusses the problems faced by adolescent girls in trying to retain a sense of self.