Once Upon a Time in Mexico (2003) is an action film by Robert Rodriguez, the capper to the "El Mariachi" trilogy, which includes El Mariachi and Desperado. Antonio Banderas reprises his role as El Mariachi. The film also stars Johnny Depp, Salma Hayek, Willem Dafoe, Enrique Iglesias, Mickey Rourke, and Rubén Blades

The plot centers once again on El Mariachi, who is recruited by Sands, a mysterious CIA agent, to assist the assassination of the President of Mexico at the hands of a Mexican crime boss. Sands is a psychopathic cold-blooded individual who manipulates several others into doing his bidding.

El Mariachi recruits his two friends to assist him. Learning that General Marquez, the one person who is responsible for the death of his wife (Salma Hayek) and daughter, is meant by Sands to assassinate the current president, El and his companions choose to help the president and prevent the coup.

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