Little Italy is a general name for an ethnic enclave populated (or formerly populated) primarily by Italians. It can also be the name of a specific Italian neighbourhood, as in these cities:

• Little Italy in Baltimore, Maryland
• Little Italy in Cleveland, Ohio
• Little Italy in Manhattan, New York, New York
• Little Italy in San Diego, California
• Little Italy in Syracuse, New York
• Little Italy in Toronto, Ontario

Some Italian neighborhoods may have other names, but are colloquially referred to as "Little Italy," including:

• Belmont /Arthur Avenue, The Bronx, New York City (sometimes known as the Little Italy of the Bronx)
• The First Ward in Newark, New Jersey, now known as "Seventh Avenue."
• The Italian Market in Philadelphia, Pennsylvania.
• The Hill, Saint Louis
• North End, Boston
• North Beach, San Francisco