Khairpur (khīr´poor) is a city in the Sind province in southeast Pakistan. In 1981, its population was 61,447. Khairpur trades in wheat, cotton, tobacco, and dates and is linked by road and rail to Karachi. Manufactures include textiles, carpets, refined sugar, and leather goods.

The city was the capital of the former princely state of Khairpur, which was founded in 1783 and merged into Pakistan in 1955. It is a cultural center with fine historic buildings, notably the Faiz Palace, Kotdiji Fort, and Shah Abdul Latif University.