John Edward McCullough (November 2 1837 - November 8 1885) was an American actor.

He was born in Coleraine, Ireland. He went to America at the age of sixteen, and made his first appearance on the stage at the Arch Street Theatre , Philadelphia, in 1857. In support of Edwin Forrest and Edwin Booth he played second roles in Shakespearean and other tragedies, and Forrest left him by will all his prompt books. Tirginius was his greatest success, although even in this part and as Othello he was coldly received in England (1881). In 1884 he broke down physically and mentally, and he died in an asylum at Philadelphia.