The title Baron Saye and Sele was created in the Peerage of England in 1447, when letters patent granted the title to James Fiennes (c.1395-1450) for his services in the Hundred Years War.

In 1423 James Fiennes, 1st Baron Saye and Sele became the Baron of Hever Castle from Sir Roger Fiennes who first obtained the castle. James Fiennes' son, William Fiennes, 2nd Baron Saye and Sele (c. 1428-1471) inherited the castle and barony in 1430. At the death of his son, the 2nd Baron, the title became dormant.

Lord Saye and Sele was lord chamberlain and lord treasurer under King Henry VI of England but was beheaded by the rebels in London under Captain Jack Cade on July 4 1450.

|- style="text-align: center;" | width="30%" |Preceded by:
Marmaduke Lumley | width="40%" style="text-align: center;" |Lord High Treasurer
1449–1450 | width="30%" |Succeeded by:
The Lord Beauchamp of Powick