Herennius Modestinus was a celebrated Roman jurist, a student of Ulpian who flourished about 250.

He appears to have been a native of one of the Greek-speaking provinces, probably Dalmatia. In Valentinian's Law of Citations he is classed with Papinian, Paulus, Gaius and Ulpian, as one of the five jurists whose recorded views were considered decisive.

He is mentioned in a rescript of Gordian III in the year 240 in connection with a responsum which he gave to the party to whom the rescript was addressed. No fewer than 345 passages in the Digest of the Corpus Juris Civilis are taken from his writings.