George John Spencer, 2nd Earl Spencer (1 September 1758 - 10 November 1834) was a Whig politician of the late 18th and early 19th century. He served under Pitt as First Lord of the Admiralty from 1794 to 1801, and then in the Ministry of All the Talents as Home Secretary. He was noted for his interest in literature. Several of his close relations were more famous than he. His son Lord Althorp was one of the chief architects of the passage of the Great Reform Bill in 1832. His sister Georgiana married the Duke of Devonshire and became a famed Whig hostess.

|- style="text-align: center;" | width="30%" |Preceded by:
The Earl of Chatham | width="40%" style="text-align: center;" |First Lord of the Admiralty
1794–1801 | width="30%" |Succeeded by:
The Earl of St Vincent

|- style="text-align: center;" | width="30%" |Preceded by:
The Lord Hawkesbury | width="40%" style="text-align: center;" |Home Secretary
1806–1807 | width="30%" |Succeeded by:
The Lord Hawkesbury