Cocawine was an alcoholic beverage that combined wine and cocaine. The most popular brand was Vin Mariani developed in 1863 by Corsican entrepreneur Angelo Mariani. It was a popular drink at the time.

In Atlanta, John Pemberton, a pharmacist, developed his own cocktail based on Vin Mariani and called it Pemberton's French Wine Coca. It proved popular among American consumers. But in 1886, when Georgia introduced Prohibition, he had to replace the wine in his recipe with non-alcoholic syrup. The new recipe was the origin of Coca-cola.

At the end of the 19th century, the fear of drug abuse made coca-based drinks less popular. This eventually led to the outlawing of cocaine in the United States, and the removal of cocaine from coca-cola.