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Berenice was the daughter of Ptolemy Philadelphus. In ca. 250 BC she married the Seleucid monarch Antiochus II Theos, who, following an agreement with Ptolemy (249 BC), had divorced his wife Laodice and transferred the succession to Berenice's children. On Ptolemy's death, Antiochus repudiated Berenice and took back Laodice, who, however, at once poisoned him and murdered Berenice and her son.