Manius Acilius Glabrio was a Roman consul, general, and member of a plebeian family.

Glabrio became roman consul in 191 BC, defeated Antiochus the Great of Syria at the Battle of Thermopylae , and compelled him to leave Greece. He then turned his attention to the Aetolians, who had persuaded Antiochus to declare war against Rome, and was only prevented from crushing them by the intercession of Titus Quinctius Flamininus.

In 189 BC Glabrio was a candidate for the censorship, but was opposed by the nobles. He was accused by the tribunes of having concealed a portion of the Syrian spoils in his own house; his legate gave evidence against him, and he withdrew his candidature. It is probable that he was the author of the law which left it to the discretion of the pontiffs to insert or omit the intercalary month of the year.